EcoGene

GenePage for the csrD gene of Escherichia coli K-12

Primary Gene Name: csrD
EcoGene Accession Number: EG10018
K-12 Gene Accession Number: ECK3240
MG1655 Gene Identifier: b3252

Common Core

CommonCore-5

Cyclic-di-GMP phosphodiesterase

Diguanylate cyclase

Dual GGDEF/EAL domain proteins

Glycogen-deficiency ASKA clones

InnerMemProt

InnerMemProt_Pi

Y-synonyms

Gene Name Mnemonic: Carbon storage regulator

Alternate Gene Symbols: yhdA

Description:
Targets csrBC sRNAs for degradation by RNase E; degenerate GGDEF/EAL protein; carbon flux regulator; indirectly affects CsrA function

Pre-Run BlastP UniProt

Protein Sequence: ------------ MW: 73339.24------646 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 3399414 ----------------- Counterclockwise ----------------- Right End: 3401354
Left Inter Gene Info Minute or Centisome (%) = 73.27 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

In its c-di-GMP domains CsrD has HRSDF instead of GGDEF and ELM instead of EAL and does not appear to have either diguanylate cyclase or cyclic-di-GMP phosphodiesterase activities and the role of CsrD in csrB/C destabilization does not involve cyclic-di-GMP metabolism (Suzuki, 2006). There is a very low level of CsrD expression and CsrD may work at substoichiometric concentrations (Suzuki, 2006). False positive lipoprotein prediction, Cys not conserved.