EcoGene

GenePage for the mraY gene of Escherichia coli K-12

Primary Gene Name: mraY
EcoGene Accession Number: EG10604
K-12 Gene Accession Number: ECK0088
MG1655 Gene Identifier: b0087

Gene Name Mnemonic: Murein cluster a

Alternate Gene Symbols: murX

Description:
UDP-N-acetylmuramoyl-pentapeptide:undecaprenyl-PO4 phosphatase

Pre-Run BlastP UniProt

Protein Sequence: ------------ MW: 39874.75------360 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 96002 ----------------- Clockwise ----------------- Right End: 97084
Left Inter Gene Info Minute or Centisome (%) = 2.07 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

The aspartic acid residues DD115, D116, and D267 are necessary for catalysis.  The model suggested indicates that D115 and D116 chelate the Mg2+ cofactor, which in turn binds the pyrophosphate bridge of the UDP-MurNAc-pentapeptide, and D267 acts as the catalytic nucleophile.