EcoGene

GenePage for the panD gene of Escherichia coli K-12

Primary Gene Name: panD
EcoGene Accession Number: EG11747
K-12 Gene Accession Number: ECK0130
MG1655 Gene Identifier: b0131

Common Core

CommonCore-5

Gene Name Mnemonic: Pantothenate

Alternate Gene Symbols: None

Description:
Aspartate 1-decarboxylase; pantothenate biosynthesis; residues 1-24 cleaved, constitute the beta chain; C-terminal (102aa) constitutes alpha chain

Pre-Run BlastP UniProt

Protein Sequence: ------------ MW: 13833.73------126 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 146314 ----------------- Counterclockwise ----------------- Right End: 146694
Left Inter Gene Info Minute or Centisome (%) = 3.15 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

Mutants have altered acyl-CoA pools. N-terminus of alpha subunit (Ser25) is modified to pyruvic acid and involved in catalysis. Replacing normally modified Ser25 with an alanine inactivates PanD. Sequencing citation: Merkel,W.K. and Nichols,B.P., Nucleotide sequence of the Escherichia coli panBCD gene cluster, unpublished (1993) as cited in GenBank accession number L17086. Aspartate decarboxylase activity was confirmed in K-12 when it was first shown to be PanD (Cronan, 1980).