EcoGene

GenePage for the mgtA gene of Escherichia coli K-12

Primary Gene Name: mgtA
EcoGene Accession Number: EG12525
K-12 Gene Accession Number: ECK4237
MG1655 Gene Identifier: b4242

34 Active Assayable Promoters

Common Core

CommonCore-5

Glycogen Content Mutants

Glycogen Deficient Mutants

Oxidized Proteins, Nitrogen

Gene Name Mnemonic: Magnesium transport

Alternate Gene Symbols: corB, mgt

Description:
Magnesium transporter, ATP-dependent; mutant has cobalt resistance; mediates Mg(2+) influx

Pre-Run BlastP UniProt

Protein Sequence: ------------ MW: 99466.49------898 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 4465648 ----------------- Clockwise ----------------- Right End: 4468344
Left Inter Gene Info Minute or Centisome (%) = 96.25 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

Mg(2+) stimulon-PhoPQ regulon, EvgAS-PhoPQ cascade enhanced-expression subset. Salmonella mgtA is regulated by a Mg(2+)-responsive riboswitch which attenuates transcription; the mgtA 5' UTR secondary structure is conserved in E. coli and the E. coli mgtA 5' UTR functions as a Mg(2+)-responsive riboswitch in a synthetic construct (Groisman, 2006; Cromie, 2006). In addition to the PhoP-regulated P1 promoter, there is a constitutive P2 promoter 83 nt upstream of P1 (Kato, 1999; Yamamoto, 2002; Minagawa, 2003). The mgtA riboswitch senses external Mg(2+) levels and, in addition to an attenuation mechanism, targets mgtA mRNA for degradation by RNase E at high external Mg(2+) levels (Spinelli, 2008). HAD superfamily: MgtA contains a putative phosphatase HAD domain at residues 367-662.