EcoGene

GenePage for the murJ gene of Escherichia coli K-12

Primary Gene Name: murJ
EcoGene Accession Number: EG13880
K-12 Gene Accession Number: ECK1054
MG1655 Gene Identifier: b1069

Gene Name Mnemonic: Murein

Alternate Gene Symbols: mviN(S.t.), mviS(S.t.), yceN

Description:
Probable peptidoglycan lipid II flippase; required for murein synthesis

Pre-Run BlastP UniProt

Protein Sequence: ------------ MW: 55267.47------511 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 1127062 ----------------- Clockwise ----------------- Right End: 1128597
Left Inter Gene Info Minute or Centisome (%) = 24.29 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

murJ(yceN) is an essential gene and conditional lethal mutants swell, burst and accumulate the murein intermediate polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine at the non-permissive temperature (Inoue, 2008). murJ(yceN) was identified as one of two ORFs adjacent to the flg locus in a region originally named mviS, then renamed mviN and mviM when sequenced; mviMN was thought to be required for mouse virulence in Salmonella, but the mviMN deletion in ST39 also removed flgM (Carsiotis, 1989). flgM was later shown to be able to complement the mviS phenotype, and thus flgM is the real mouse virulence gene in this region of the Salmonella chromosome not mviS (Schmitt, 1994).