GenePage for the dcuB gene of Escherichia coli K-12

Primary Gene Name: dcuB
EcoGene Accession Number: EG10006
K-12 Gene Accession Number: ECK4116
MG1655 Gene Identifier: b4123
Gene Name Mnemonic: Dicarboxylate uptake
Alternate Gene Symbols: genF
Description: C4-dicarboxylate transporter, anaerobic; DcuS co-sensor
  # bp Upstream # bp Downstream
MW: 47935.26 ---------446 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4347404
Left Intergenic Region

Name: fumB_dcuB

Length: 77 bp gap

Orientation: Codirectional-

Left_end: 4347327

Right_end: 4347403

Centisome: 93.66

Genomic Address
Counterclockwise
Minute or Centisome (%) = 93.66
Right End: 4348744
Right Intergenic Region

Name: dcuB_dcuR

Length: 570 bp gap

Orientation: Codirectional-

Left_end: 4348745

Right_end: 4349314

Centisome: 93.69

DcuB is a bifunctional protein with both transporter and co-sensor functions; some mutations affect DcuRS-mediated transcriptional regulation but not transport and vice-versa (Kleefeld, 2009; Bauer, 2011). IT (Ion Transporter) superfamily (Prakash, 2003). ST(3) structural class based on hydropathy profile (Lolkema, 2003). DcuB is required for D-tartrate anaerobic transport (Kim, 2007).

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BamHI EcoRI HindIII