GenePage for the bglG gene of Escherichia coli K-12
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Primary Gene Name: bglG EcoGene Accession Number: EG10116 K-12 Gene Accession Number: ECK3716 MG1655 Gene Identifier: b3723 |
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Gene Name Mnemonic: beta-Glucoside Alternate Gene Symbols: bglC; bglR; bglS Description: Transcription antiterminator for cryptic bglGFBH operon; RNA-binding protein; dimerization and activity modulated by phosphorylation state; binds kinase/dephosphorylase BglF |
| MW: 32097.14 ---------278 aa |
Pre-Run BlastP UniProt Pre-Run BlastP NR+Env |
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Left End: 3905731 Left Intergenic Region Name: bglF_bglG Length: 133 bp gap Orientation: Codirectional- Left_end: 3905598 Right_end: 3905730 Centisome: 84.14 |
Genomic Address Counterclockwise Minute or Centisome (%) = 84.15 |
Right End: 3906567 Right Intergenic Region Name: bglG_phoU Length: 285 bp gap Orientation: Codirectional- Left_end: 3906568 Right_end: 3906852 Centisome: 84.16 |
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The non-phosphorylated BglG dimer binds to RNA and allows readthrough of transcription. BglG has an N-terminal RNA-binding domain followed by two PTS-regulation and dimerization (PRD) domains, PRD1 and PRD2, which contain the phosphorylated sites. BglG is activated by phospho-HPr(PtsH)-mediated phosphorylation and is deactivated by BglF-mediated phosphorylation at a second site; the inducing beta-glucoside sugar causes BglF to dephosphylate BglG at the second site, leading to cytoplasmic localization of BglG, BglG dimerization, and activation of BglG-mediated antitermination of the bgl operon (Amster-Choder, 1992; Görke, 1999). BglG is homologus to LicT of B. subtilis.
