GenePage for the cadA gene of Escherichia coli K-12
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Primary Gene Name: cadA EcoGene Accession Number: EG10131 K-12 Gene Accession Number: ECK4125 MG1655 Gene Identifier: b4131 |
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Gene Name Mnemonic: Cadaverine Alternate Gene Symbols: ldcI Description: Lysine decarboxylase, inducible; decameric |
| Verified Start | MW: 81260.12 ---------715 aa |
Pre-Run BlastP UniProt Pre-Run BlastP NR+Env |
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Left End: 4356470 Left Intergenic Region Name: dtpC_cadA Length: 58 bp gap Orientation: Codirectional- Left_end: 4356412 Right_end: 4356469 Centisome: 93.85 |
Genomic Address Counterclockwise Minute or Centisome (%) = 93.86 |
Right End: 4358617 Right Intergenic Region Name: cadA_cadB Length: 79 bp gap Orientation: Codirectional- Left_end: 4358618 Right_end: 4358696 Centisome: 93.90 |
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ppGpp binds to and inhibits CadA(LdcI) in vitro and in vivo (Kanjee, 2011). Induction of the cadAB operon under acidic conditions and in the presence of lysine neutralized the extracellular environment and enables production of CO(2); production of cadaverine and aminopropylcadaverine instead of putrescine and spermidine also resulted. cadAB operon induction also generated a proton motive force. Lack of cadBA operon induction results in an increase in speF-potE operon expression. CadA(LdcI) is required for full pathogenicity of Salmonella and Vibrio. CadA(LdcI) and RavA ATPase form a complex.
