GenePage for the cytR gene of Escherichia coli K-12

Primary Gene Name: cytR
EcoGene Accession Number: EG10200
K-12 Gene Accession Number: ECK3926
MG1655 Gene Identifier: b3934
Gene Name Mnemonic: Cytidine catabolism regulator
Alternate Gene Symbols: None
Description: Anti-activator for nucleoside utilization regulon
  # bp Upstream # bp Downstream
MW: 37819.78 ---------341 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4123431
Left Intergenic Region

Name: ftsN_cytR

Length: 91 bp gap

Orientation: Codirectional-

Left_end: 4123340

Right_end: 4123430

Centisome: 88.83

Genomic Address
Counterclockwise
Minute or Centisome (%) = 88.84
Right End: 4124456
Right Intergenic Region

Name: cytR_priA

Length: 155 bp gap

Orientation: Codirectional-

Left_end: 4124457

Right_end: 4124611

Centisome: 88.86

CytR and CRP cooperate to regulate genes involved in nucleoside utiization; CytR binds DNA weakly by itself but CytR binding directly to CRP stabilizes CytR binding to DNA and blocks CRP-mediated activation although CRP remains bound to DNA; release of CytR by cytidine binding allows for re-activation of transcription by CRP-cAMP (Valentin-Hansen, 1996) The CytR-CRP complex is a dual regulation transcription factor complex that is able to activate some promoters rather than repress, depending on the DNA context (Rasmussen, 1996). cytR mutants show improved growth on uridine. Eight target genes (deoC, cdd, ppiA, tsx, nupC, nupG, udp, rpoH) and auto-regulation of cytR constitute the CytR regulon; a tenth gene encoding an inner membrane protein, ycdZ(nupT), is predicted to be regulated by CytR-CRP based on conserved CytR and CRP binding sites but there is no experimental evidence for either YcdZ function or regulation of ycdZ (Sernova, 2012).

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BamHI EcoRI HindIII