GenePage for the dppA gene of Escherichia coli K-12
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Primary Gene Name: dppA EcoGene Accession Number: EG10248 K-12 Gene Accession Number: ECK3531 MG1655 Gene Identifier: b3544 |
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Gene Name Mnemonic: Dipeptide permease system Alternate Gene Symbols: alu; dpp; fpp Description: Dipeptide/heme ABC transporter periplasmic binding protein; for transport and chemotaxis |
| Verified Start | MW: 60293.67 ---------535 aa |
Pre-Run BlastP UniProt Pre-Run BlastP NR+Env |
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Left End: 3706098 Left Intergenic Region Name: dppB_dppA Length: 307 bp gap Orientation: Codirectional- Left_end: 3705791 Right_end: 3706097 Centisome: 79.84 |
Genomic Address Counterclockwise Minute or Centisome (%) = 79.84 |
Right End: 3707705 Right Intergenic Region Name: dppA_proK Length: 910 bp gap Orientation: Codirectional- Left_end: 3707706 Right_end: 3708615 Centisome: 79.88 |
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DppA binds dipeptides and heme, and mediates chemotaxis to dipeptides through the Tap chemoreceptor. E. coli does not normally use exogeneous heme, but heme can be utilized if a foreign OM heme receptor is expressed in E. coli; heme and dipeptides compete for the same binding site; MppA is an alternative heme periplasmic binding protein; MppA or DppA is required for the uptake of 5-aminolevulinic acid (Letoffe, 2006). After four hours of Zn(II) stress, DppA protein levels decreased (Easton, 2006).
