GenePage for the fecR gene of Escherichia coli K-12

Primary Gene Name: fecR
EcoGene Accession Number: EG10292
K-12 Gene Accession Number: ECK4282
MG1655 Gene Identifier: b4292
Gene Name Mnemonic: Ferric citrate
Alternate Gene Symbols: None
Description: Anti-sigma-19 ferric citrate transmembrane signal transducer; periplasmic signal receiver for FecA-bound extracellular ferric citrate and transmittor for cytoplasmic sigma-19 activation
  # bp Upstream # bp Downstream
MW: 35532.06 ---------317 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4516764
Left Intergenic Region

Name: fecA_fecR

Length: 86 bp gap

Orientation: Codirectional-

Left_end: 4516678

Right_end: 4516763

Centisome: 97.31

Genomic Address
Counterclockwise
Minute or Centisome (%) = 97.31
Right End: 4517717
Right Intergenic Region

Name: fecR_fecI

Length: 4 bp overlap

Orientation: Codirectional-

Left_end: 4517714

Right_end: 4517717

Centisome: 97.33

The cytoplasmic C-terminal domain of FecR is an anti-sigma-19 factor, but sigma-19 (FecI) also requires FecR to function; in the absence of ferric citrate FecI is bound to the membrane by the cytoplasmic domain of the FecR transmembrane signal transducer, which both sequesters FecI and activates or protects FecI; exogenous ferric citrate induces outer membrane transmembrane transducer FecA to signal inner membrane transmembrane transducer FecR to release membrane-bound FecI to bind cytoplasmic core RNA polymerase and activate Fur-dependent fec operon transcription to allow ferric citrate import and relief of iron starvation (Braun, 2006; TreviƱo-Quintanilla, 2013). A fecR mutant has increased cell aggregation and biofilm formation (Brombacher, 2006). The Fec iron uptake and transmembrane signaling diferric dicitrate substrate [Fe(3+) citrate]2, is more simply referred to as ferric citrate (Braun, 2005).

Go to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePage

BamHI EcoRI HindIII