GenePage for the flhC gene of Escherichia coli K-12

Primary Gene Name: flhC
EcoGene Accession Number: EG10319
K-12 Gene Accession Number: ECK1892
MG1655 Gene Identifier: b1891
Gene Name Mnemonic: Flagella
Alternate Gene Symbols: flaI
Description: Transcriptional activator of flagellar class II operons; forms heterotetramer with FlhD; CsrA regulon; may be allosteric effector of FlhD
  # bp Upstream # bp Downstream
MW: 21566.09 ---------192 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1977266
Left Intergenic Region

Name: motA_flhC

Length: 126 bp gap

Orientation: Codirectional-

Left_end: 1977140

Right_end: 1977265

Centisome: 42.60

Genomic Address
Counterclockwise
Minute or Centisome (%) = 42.60
Right End: 1977844
Right Intergenic Region

Name: flhC_flhD

Length: 2 bp gap

Orientation: Codirectional-

Left_end: 1977845

Right_end: 1977846

Centisome: 42.61

pgsA mutants are non-motile due to elevated RpoS levels that repress flhDC transcription; pgsA3 multicopy suppressers gadW, metE and nudL(yeaB) act by increasing RpoS levels (Uchiyama, 2010). YdiV functions as an anti-FlhD4C2 factor in vitro, binding FlhD4C2 and blocking its activation of the flagellar regulon; YdiV is poorly translated explaining why E. coli does not have reduced motility at low nutrient concentrations mediated by YdiV and alleviated by fliZ mutation (Wada, 2012).

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BamHI EcoRI HindIII