GenePage for the flhD gene of Escherichia coli K-12

Primary Gene Name: flhD
EcoGene Accession Number: EG10320
K-12 Gene Accession Number: ECK1893
MG1655 Gene Identifier: b1892
Gene Name Mnemonic: Flagella
Alternate Gene Symbols: flbB
Description: Transcriptional activator of flagellar class II operons; forms heterotetramer with FlhC
  # bp Upstream # bp Downstream
MW: 13316.40 ---------116 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1977847
Left Intergenic Region

Name: flhC_flhD

Length: 2 bp gap

Orientation: Codirectional-

Left_end: 1977845

Right_end: 1977846

Centisome: 42.61

Genomic Address
Counterclockwise
Minute or Centisome (%) = 42.61
Right End: 1978197
Right Intergenic Region

Name: flhD_insB8

Length: 320 bp gap

Orientation: Codirectional-

Left_end: 1978198

Right_end: 1978517

Centisome: 42.62

pgsA mutants are non-motile due to elevated RpoS levels that repress flhDC transcription; pgsA3 multicopy suppressers gadW, metE and nudL(yeaB) act by increasing RpoS levels (Uchiyama, 2010). RflP(YdiV) functions as an anti-FlhD4C2 factor, binding FlhD4C2 and blocking its activation of the flagellar regulon; RflP(YdiV) is poorly translated explaining why E. coli does not have reduced motility at low nutrient concentrations mediated by RflP(YdiV) and alleviated by fliZ mutation (Wada, 2012). CsrA regulon.

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BamHI EcoRI HindIII