GenePage for the fruA gene of Escherichia coli K-12

Primary Gene Name: fruA
EcoGene Accession Number: EG10336
K-12 Gene Accession Number: ECK2160
MG1655 Gene Identifier: b2167
Gene Name Mnemonic: Fructose
Alternate Gene Symbols: ptsF
Description: Fructose permease, PTS Enzyme IIBC component
  # bp Upstream # bp Downstream
MW: 57519.11 ---------563 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2259719
Left Intergenic Region

Name: psuK_fruA

Length: 422 bp gap

Orientation: Codirectional-

Left_end: 2259297

Right_end: 2259718

Centisome: 48.67

Genomic Address
Counterclockwise
Minute or Centisome (%) = 48.68
Right End: 2261410
Right Intergenic Region

Name: fruA_fruK

Length: 16 bp gap

Orientation: Codirectional-

Left_end: 2261411

Right_end: 2261426

Centisome: 48.72

FruA has two N-terminal fructose-specific EIIB regulatory domains and a C-terminal EIIC permease channel domain. In the probable fructose-specific PTS kinase cascade, the autophosphorylated enzyme I (PtsI) His189-P transfers a phosphate to His299 in the HPr-like FPr domain of FruB; His299-P transfers a phosphate to His62 of the FruB EIIA domain; His62-P transfers its phosphate to Cys112 of the EIIB domain of FruA and from EIIB to fructose during sugar uptake. The FruA C-terminal domain, the last 200 residues, is a member of LysE superfamily.

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BamHI EcoRI HindIII