GenePage for the ftsI gene of Escherichia coli K-12

Primary Gene Name: ftsI
EcoGene Accession Number: EG10341
K-12 Gene Accession Number: ECK0085
MG1655 Gene Identifier: b0084
Gene Name Mnemonic: Filamentation, temperature sensitive
Alternate Gene Symbols: pbpB; sep
Description: Transpetidase, PBP3; penicillin-binding protein 3 involved in septal peptidoglycan synthesis
  # bp Upstream # bp Downstream
MW: 63877.43 ---------588 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 91413
Left Intergenic Region

Name: ftsL_ftsI

Length: 15 bp gap

Orientation: Codirectional+

Left_end: 91398

Right_end: 91412

Centisome: 1.97

Genomic Address
Clockwise
Minute or Centisome (%) = 1.97
Right End: 93179
Right Intergenic Region

Name: ftsI_murE

Length: 14 bp overlap

Orientation: Codirectional+

Left_end: 93166

Right_end: 93179

Centisome: 2.01

FtsI is recruited by its cognate SEDS protein FtsW. ftsI is an ssential gene (Hara, 1997). FtsI was reported to be a lipoprotein, but only 15% of the protein was modified; the physiological significance of this is unknown and the leader sequence is not predicted to have a lipoprotein cleavage site (Hayashi, 1988). Divisome protein. FtsN has been shown by FRET to directly interact with itself, FtsW, FtsI and ZapA (Alexeeva, 2010). ZapA has been shown by FRET to directly interact with itself, FtsN, FtsZ and FtsI (Alexeeva, 2010).

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BamHI EcoRI HindIII