GenePage for the ispG gene of Escherichia coli K-12

Primary Gene Name: ispG
EcoGene Accession Number: EG10370
K-12 Gene Accession Number: ECK2511
MG1655 Gene Identifier: b2515
Gene Name Mnemonic: Isoprenoid
Alternate Gene Symbols: gcpE
Description: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; alternative nonmevalonate (DXP) pathway for terpenoid biosynthesis; [4Fe-4S] protein
  # bp Upstream # bp Downstream
MW: 40683.61 ---------372 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2640686
Left Intergenic Region

Name: hisS_ispG

Length: 110 bp gap

Orientation: Codirectional-

Left_end: 2640576

Right_end: 2640685

Centisome: 56.89

Genomic Address
Counterclockwise
Minute or Centisome (%) = 56.89
Right End: 2641804
Right Intergenic Region

Name: ispG_rodZ

Length: 26 bp gap

Orientation: Codirectional-

Left_end: 2641805

Right_end: 2641830

Centisome: 56.92

The IspG substrate is 2C-methyl-d-erythritol 2,4-cyclodiphosphate. In vitro activity requires auxiliary protein(s), probably as shuttles for redox equivalents. E. coli ispG(gcpE) complements the P. stuartii aarC1 defect in quorum sensing regulation of gene expression. The ispG gene is essential. otherPDB (A. aeolicus): 3NOY. otherPDB (T. thermophilus): 2Y0F.

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BamHI EcoRI HindIII