GenePage for the guaB gene of Escherichia coli K-12

Primary Gene Name: guaB
EcoGene Accession Number: EG10421
K-12 Gene Accession Number: ECK2504
MG1655 Gene Identifier: b2508
Gene Name Mnemonic: Guanine
Alternate Gene Symbols: guaR
Description: Inosine-5'-monophosphate (IMP) dehydrogenase
  # bp Upstream # bp Downstream
Verified Start MW: 52022.45 ---------488 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2632604
Left Intergenic Region

Name: guaA_guaB

Length: 68 bp gap

Orientation: Codirectional-

Left_end: 2632536

Right_end: 2632603

Centisome: 56.72

Genomic Address
Counterclockwise
Minute or Centisome (%) = 56.72
Right End: 2634070
Right Intergenic Region

Name: guaB_xseA

Length: 161 bp gap

Orientation: Divergent

Left_end: 2634071

Right_end: 2634231

Centisome: 56.75

GuaB binds CT-rich ssDNA (Kozhevnikova, 2012). De novo biosynthesis of guanine nucleotides is rate-limited by IMP. IMP has two regions, one catalytic domain and the other a functionally conserved single-stranded nucleic acid binding subdomain.

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BamHI EcoRI HindIII