GenePage for the hflC gene of Escherichia coli K-12

Primary Gene Name: hflC
EcoGene Accession Number: EG10435
K-12 Gene Accession Number: ECK4171
MG1655 Gene Identifier: b4175
Gene Name Mnemonic: High-frequency lysogenization
Alternate Gene Symbols: hflA
Description: Membrane bound protease complex, with FtsH and HflK; regulates lysogeny; non-essential
  # bp Upstream # bp Downstream
MW: 37649.88 ---------334 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4403300
Left Intergenic Region

Name: hflK_hflC

Length: 2 bp gap

Orientation: Codirectional+

Left_end: 4403298

Right_end: 4403299

Centisome: 94.86

Genomic Address
Clockwise
Minute or Centisome (%) = 94.86
Right End: 4404304
Right Intergenic Region

Name: hflC_yjeT

Length: 81 bp gap

Orientation: Codirectional+

Left_end: 4404305

Right_end: 4404385

Centisome: 94.89

Gain-of-function alleles in hflC and hflK inhibit FtsH-mediated degradation of uncomplexed SecY protein and other membrane protein substrates. Null hflC or hflK alleles stabilize cytoplasmic substrate cII. hflCK is a multicopy suppressor of ftsH htpX double mutant. Serine protease-like motif in HflC not required for cII degradation. HflC and HflK have periplasmic prohibitin homology (PHB) domains. The PHB domain is also called the SPFH domain, named after the proteins Stomatin, Prohibitin, Flotillin and HflK/C (Tavernarakis, 1999; Morrow, 2005; Rivera-Milla, 2006; Browman, 2007). HflC belongs to subfamily SPFH3b (Hinderhofer, 2009). HT_Cmplx45_Mem: HflC+HybC+BamB.

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BamHI EcoRI HindIII