GenePage for the degP gene of Escherichia coli K-12

Primary Gene Name: degP
EcoGene Accession Number: EG10463
K-12 Gene Accession Number: ECK0160
MG1655 Gene Identifier: b0161
Gene Name Mnemonic: Degradative protease
Alternate Gene Symbols: htrA; ptd
Description: Periplasmic, membrane-associated serine endoprotease; protease Do, required for high-temperature growth and the degradation of damaged proteins, primarily outer membrane proteins
  # bp Upstream # bp Downstream
Verified Start MW: 49354.23 ---------474 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 180884
Left Intergenic Region

Name: dgt_degP

Length: 129 bp gap

Orientation: Codirectional+

Left_end: 180755

Right_end: 180883

Centisome: 3.89

Genomic Address
Clockwise
Minute or Centisome (%) = 3.90
Right End: 182308
Right Intergenic Region

Name: degP_cdaR

Length: 154 bp gap

Orientation: Codirectional+

Left_end: 182309

Right_end: 182462

Centisome: 3.93

Autocleavage of DegP occurs after Cys95(Cys69 of mature form) or Gln108 (Gln82 of mature form). Autocleavage of DegP causes hexameric DegP(HtrA) to dissociate into proteolytically active monomers. DegP is targeted to some proteins by CpxP. Sigma E promoter. degP mutants have elevated OM vesiculation (McBroom, 2006). DegP(HtrA) has chaperone activity in vitro as demonstrated by efficient inhibition of the unfolded lysozyme aggregation (Skorko-Glonek, 2007). DegP is associated with outer membrane proteins (OMPs) and is required for the degradation of unfolded OMPs; DegP(HtrA) has very little chaperone activity in cells (Ge, 2013).

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BamHI EcoRI HindIII