GenePage for the hypA gene of Escherichia coli K-12

Primary Gene Name: hypA
EcoGene Accession Number: EG10483
K-12 Gene Accession Number: ECK2721
MG1655 Gene Identifier: b2726
Gene Name Mnemonic: Hydrogenase pleiotropic
Alternate Gene Symbols: None
Description: Hydrogenase 3 accessory protein required for activity; zinc metalloprotein
  # bp Upstream # bp Downstream
MW: 13168.17 ---------116 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2850647
Left Intergenic Region

Name: hycA_hypA

Length: 211 bp gap

Orientation: Divergent

Left_end: 2850436

Right_end: 2850646

Centisome: 61.41

Genomic Address
Clockwise
Minute or Centisome (%) = 61.41
Right End: 2850997
Right Intergenic Region

Name: hypA_hypB

Length: 3 bp gap

Orientation: Codirectional+

Left_end: 2850998

Right_end: 2851000

Centisome: 61.42

HypA is a zinc metalloprotein with a separate weak nickel binding site (Atanassova, 2005). HypA and HypB form a complex (Atanassova, 2005). hypA mutants have increased Hydrogenase 2 activity but similar amounts of HypA protein. hypA defect suppressed by expression of hypB-E under foreign promoter, indicating a regulatory or partially redundant function. Paralogous to hybF.

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BamHI EcoRI HindIII