GenePage for the iclR gene of Escherichia coli K-12

Primary Gene Name: iclR
EcoGene Accession Number: EG10491
K-12 Gene Accession Number: ECK4010
MG1655 Gene Identifier: b4018
Gene Name Mnemonic: Isocitrate lyase
Alternate Gene Symbols: None
Description: Repressor of aceBA operon
  # bp Upstream # bp Downstream
Verified Start MW: 29739.28 ---------274 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4222804
Left Intergenic Region

Name: arpA_iclR

Length: 316 bp gap

Orientation: Codirectional-

Left_end: 4222488

Right_end: 4222803

Centisome: 90.97

Genomic Address
Counterclockwise
Minute or Centisome (%) = 90.98
Right End: 4223628
Right Intergenic Region

Name: iclR_metH

Length: 199 bp gap

Orientation: Divergent

Left_end: 4223629

Right_end: 4223827

Centisome: 90.99

Tetrameric (dimer of dimers) IclR binds to the aceBA operator and dimeric IclR is inactive; glyoxylate dissociates IclR and favors dimers; pyruvate promotes binding and favors tetramers (Lorca, 2007). AllR(GclR) and IclR can bind to the same DNA sequence so IclR binds to the AllR(GclR) binding site at the gcl promoter but a deletion of IclR has no effect on gcl transcription, implying other factor(s) may be involved (Walker, 2006).

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BamHI EcoRI HindIII