GenePage for the katG gene of Escherichia coli K-12

Primary Gene Name: katG
EcoGene Accession Number: EG10511
K-12 Gene Accession Number: ECK3934
MG1655 Gene Identifier: b3942
Gene Name Mnemonic: Catalase
Alternate Gene Symbols: None
Description: Catalase-peroxidase HPI, heme b-containing; hydroperoxidase I; bifunctional catalase
  # bp Upstream # bp Downstream
MW: 80023.82 ---------726 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4133835
Left Intergenic Region

Name: metF_katG

Length: 328 bp gap

Orientation: Codirectional+

Left_end: 4133507

Right_end: 4133834

Centisome: 89.05

Genomic Address
Clockwise
Minute or Centisome (%) = 89.06
Right End: 4136015
Right Intergenic Region

Name: katG_yijE

Length: 92 bp gap

Orientation: Codirectional+

Left_end: 4136016

Right_end: 4136107

Centisome: 89.11

KatG has both catalase and broad-spectrum peroxidase activities. With AhpCF, KatG protects aerobic, phosphate-starved cells from oxidative damage. N-terminus is reportedly blocked (Triggs-Raine et al, 1988.) Binds TrxA (Kumar, 2004). KatG is a tellurite reductase (Calderon, 2006). Overexpression of YchF causes hydrogen peroxide hypersensitivity probably due to direct binding and inhibition of the catalase-peroxidase KatG by YchF, dependent on the ATPase activity of YchF and regulated by the YchF phosphorylation state at Ser16; ychF transcription is repressed by OxyR (Wenk, 2012).

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BamHI EcoRI HindIII