GenePage for the katG gene of Escherichia coli K-12
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Primary Gene Name: katG EcoGene Accession Number: EG10511 K-12 Gene Accession Number: ECK3934 MG1655 Gene Identifier: b3942 |
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Gene Name Mnemonic: Catalase Alternate Gene Symbols: None Description: Catalase-peroxidase HPI, heme b-containing; hydroperoxidase I; bifunctional catalase |
| MW: 80023.82 ---------726 aa |
Pre-Run BlastP UniProt Pre-Run BlastP NR+Env |
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Left End: 4133835 Left Intergenic Region Name: metF_katG Length: 328 bp gap Orientation: Codirectional+ Left_end: 4133507 Right_end: 4133834 Centisome: 89.05 |
Genomic Address Clockwise Minute or Centisome (%) = 89.06 |
Right End: 4136015 Right Intergenic Region Name: katG_yijE Length: 92 bp gap Orientation: Codirectional+ Left_end: 4136016 Right_end: 4136107 Centisome: 89.11 |
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KatG has both catalase and broad-spectrum peroxidase activities. With AhpCF, KatG protects aerobic, phosphate-starved cells from oxidative damage. N-terminus is reportedly blocked (Triggs-Raine et al, 1988.) Binds TrxA (Kumar, 2004). KatG is a tellurite reductase (Calderon, 2006). Overexpression of YchF causes hydrogen peroxide hypersensitivity probably due to direct binding and inhibition of the catalase-peroxidase KatG by YchF, dependent on the ATPase activity of YchF and regulated by the YchF phosphorylation state at Ser16; ychF transcription is repressed by OxyR (Wenk, 2012).
