GenePage for the groS gene of Escherichia coli K-12

Primary Gene Name: groS
EcoGene Accession Number: EG10600
K-12 Gene Accession Number: ECK4136
MG1655 Gene Identifier: b4142
Gene Name Mnemonic: Growth of phage
Alternate Gene Symbols: groES; mopB; TabB
Description: Chaperonin Cpn10; GroESL small subunit GroES; phage morphogenesis
  # bp Upstream # bp Downstream
Verified Start MW: 10386.95 ---------97 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4370688
Left Intergenic Region

Name: yjeH_groS

Length: 275 bp gap

Orientation: Divergent

Left_end: 4370413

Right_end: 4370687

Centisome: 94.16

Genomic Address
Clockwise
Minute or Centisome (%) = 94.16
Right End: 4370981
Right Intergenic Region

Name: groS_groL

Length: 43 bp gap

Orientation: Codirectional+

Left_end: 4370982

Right_end: 4371024

Centisome: 94.17

groS is an essential gene (Fayet, 1989). Cells deficient in GroES and GroEL lyse due to inability to produce cell walls as a result of the reduced level of DapA, the first enzyme in the DAP synthesis pathway (McLennan, 1998). Growth below 8C is impaired due to GroESL inactivation and can be rescued by transgenic Oleispira antarctica Cpn10/60. Overproduction of GroESL can suppress tig/dnaK synthetic lethality at 30 degrees C (Ferrer, 2003). Binds TrxA (Kumar, 2004). GroS lysine K34 can be modified to N6-succinyllysine (Zhang, 2011). The groSL promoter region binds FNR and groSL expression is repressed by FNR (Federowicz, 2014).

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BamHI EcoRI HindIII