GenePage for the fumE gene of Escherichia coli K-12

Primary Gene Name: fumE
EcoGene Accession Number: EG11162
K-12 Gene Accession Number: ECK2925
MG1655 Gene Identifier: b2929
Gene Name Mnemonic: Fumarase
Alternate Gene Symbols: yggD
Description: Fumarase E, putative transcriptional regulator
  # bp Upstream # bp Downstream
MW: 19271.94 ---------169 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3074686
Left Intergenic Region

Name: yggC_fumE

Length: 4 bp overlap

Orientation: Codirectional-

Left_end: 3074686

Right_end: 3074689

Centisome: 66.24

Genomic Address
Counterclockwise
Minute or Centisome (%) = 66.24
Right End: 3075195
Right Intergenic Region

Name: fumE_yggF

Length: 21 bp gap

Orientation: Codirectional-

Left_end: 3075196

Right_end: 3075216

Centisome: 66.25

Although fumerase activiy has been demonstrated in vitro, FumE(YggD) is still predicted to be an MtlR family putative transcriptional repressor, indicating this functional assignment may be problematic (Sévin, 2017). The FumE(YggD) crystal structure from E. coli strain S.flexneri(PDB:3C8G) has 5 mismatches to the K-12 FumE(YggD); MtlR and FumE(YggD) are paralogs (Tan, 2009).

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BamHI EcoRI HindIII