GenePage for the glrR gene of Escherichia coli K-12

Primary Gene Name: glrR
EcoGene Accession Number: EG11285
K-12 Gene Accession Number: ECK2551
MG1655 Gene Identifier: b2554
Gene Name Mnemonic: GLmy-Regulating response Regulator
Alternate Gene Symbols: qseF; yfhA
Description: Response regulator regulating glmY sRNA; cognate histidine sensor kinase is GlrK(QseE)
  # bp Upstream # bp Downstream
MW: 49148.40 ---------444 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2687469
Left Intergenic Region

Name: glnB_glrR

Length: 60 bp gap

Orientation: Codirectional-

Left_end: 2687409

Right_end: 2687468

Centisome: 57.90

Genomic Address
Counterclockwise
Minute or Centisome (%) = 57.90
Right End: 2688803
Right Intergenic Region

Name: glrR_yfhG

Length: 11 bp overlap

Orientation: Codirectional-

Left_end: 2688793

Right_end: 2688803

Centisome: 57.93

Phosphorylated GlrR(QseF,YfhA) binds the glmY promoter and activates a sigma-54 (RpoN) promoter that overlaps the sigma-70 (RpoD) promoter (Reichenbach, 2009). Also characterized in an EPEC strain, QseC activates transcription of qseEGF(glrK-yfhG-glrR) in response to the autoinducer-3 (AI-3)/epinephrine/norepinephrine interkingdom signaling system (Reading, 2007). GlrK(QseE,YfhK) phosphorylates GlrR(QseF,YfhA) and has autokinase activity in vitro; GlrR(QseF,YfhA) is also phosphorylated in vitro by non-cognate sensors UhpB, BaeS, EnvZ and RstB (Yamamoto, 2005). QseEF(GlrKR) responds directly to epinephrine, sulfate and phosphate (Reading, 2009).

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BamHI EcoRI HindIII