GenePage for the fliZ gene of Escherichia coli K-12

Primary Gene Name: fliZ
EcoGene Accession Number: EG11356
K-12 Gene Accession Number: ECK1920
MG1655 Gene Identifier: b1921
Gene Name Mnemonic: Flagella
Alternate Gene Symbols: yedH
Description: DNA-binding RpoS antagonist; transiently inhibits RpoS in post-exponential phase; timing factor allowing motility to continue for a while during starvation; not required for normal motility
  # bp Upstream # bp Downstream
MW: 21657.82 ---------183 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2000473
Left Intergenic Region

Name: fliY_fliZ

Length: 87 bp gap

Orientation: Codirectional-

Left_end: 2000386

Right_end: 2000472

Centisome: 43.10

Genomic Address
Counterclockwise
Minute or Centisome (%) = 43.10
Right End: 2001024
Right Intergenic Region

Name: fliZ_fliA

Length: 45 bp gap

Orientation: Codirectional-

Left_end: 2001025

Right_end: 2001069

Centisome: 43.11

FliZ acts by binding DNA at RpoS -10 sites and elsewhere (Pesavento, 2012). FliZ antagonizes Crl activation of a subset of RpoS-dependent promoters, without changing RpoS levels, and thus resembles an anti-sigma factor at Crl-stimulated RpoS promoters (Pesavento, 2008). FliZ may also regulate FliA (sigma 28). The motility defect of yhjH mutations is suppressed by multicopy yfgF and by mutations in ycgR, fliZ, yfiR, yegE, crfC(yjdA), and yjcZ (Girgis, 2007). Pfam PF02899 Integrase_SAM-like_N_phage.

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BamHI EcoRI HindIII