GenePage for the folK gene of Escherichia coli K-12

Primary Gene Name: folK
EcoGene Accession Number: EG11374
K-12 Gene Accession Number: ECK0141
MG1655 Gene Identifier: b0142
Gene Name Mnemonic: Folate
Alternate Gene Symbols: None
Description: 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase; monomeric
  # bp Upstream # bp Downstream
Verified Start MW: 18078.79 ---------159 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 157253
Left Intergenic Region

Name: yadN_folK

Length: 369 bp gap

Orientation: Codirectional-

Left_end: 156884

Right_end: 157252

Centisome: 3.38

Genomic Address
Counterclockwise
Minute or Centisome (%) = 3.39
Right End: 157732
Right Intergenic Region

Name: folK_pcnB

Length: 4 bp overlap

Orientation: Codirectional-

Left_end: 157729

Right_end: 157732

Centisome: 3.40

HPPK active center is formed once both substrates, ATP and HP, are bound and this assembly results in confirmational changes primarily in catalytic loops 1-3; catalytic loop 3 moves in the opposite direction upon binding of the nucleotide; catalytic loop 3 is involved in ternary complex stabilization and is necessary for catalysis.

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BamHI EcoRI HindIII