GenePage for the folE gene of Escherichia coli K-12

Primary Gene Name: folE
EcoGene Accession Number: EG11375
K-12 Gene Accession Number: ECK2146
MG1655 Gene Identifier: b2153
Gene Name Mnemonic: Folate
Alternate Gene Symbols: None
Description: GTP cyclohydrolase I
  # bp Upstream # bp Downstream
Verified Start MW: 24830.62 ---------222 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2242984
Left Intergenic Region

Name: yeiB_folE

Length: 16 bp gap

Orientation: Codirectional-

Left_end: 2242968

Right_end: 2242983

Centisome: 48.32

Genomic Address
Counterclockwise
Minute or Centisome (%) = 48.32
Right End: 2243652
Right Intergenic Region

Name: folE_yeiG

Length: 257 bp gap

Orientation: Divergent

Left_end: 2243653

Right_end: 2243909

Centisome: 48.34

Although a folE null mutant could not be made by Baba (2006), leading to its inclusion in the set of 303 essential genes, Klaus (2005) were able to construct a deletion mutation in folE. It requires LB+ thymidine and grows poorly, explaining the Baba negative result. Thus, folE is not an essential gene. FolE is the first enzyme of pre-Q(0) biosynthesis (Phillips, 2008). The yeiG-folEyeiB divergent operon promoter region binds ArcA and folE-yeiB expression is repressed by ArcA (Federowicz. 2014).

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BamHI EcoRI HindIII