GenePage for the cyaY gene of Escherichia coli K-12

Primary Gene Name: cyaY
EcoGene Accession Number: EG11653
K-12 Gene Accession Number: ECK3801
MG1655 Gene Identifier: b3807
Gene Name Mnemonic: Cyclase, adenylate
Alternate Gene Symbols: None
Description: Iron-dependent inhibitor of iron-sulfur cluster formation; binds IcsS; iron sensor; iron-binding and oxidizing protein, frataxin
  # bp Upstream # bp Downstream
MW: 12231.41 ---------106 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3993739
Left Intergenic Region

Name: cyaA_cyaY

Length: 39 bp gap

Orientation: Convergent

Left_end: 3993700

Right_end: 3993738

Centisome: 86.04

Genomic Address
Counterclockwise
Minute or Centisome (%) = 86.04
Right End: 3994059
Right Intergenic Region

Name: cyaY_yifL

Length: 462 bp gap

Orientation: Divergent

Left_end: 3994060

Right_end: 3994521

Centisome: 86.05

Frataxin-related. The previously proposed role of CyaY as an iron-sulfur cluster donor is contradicted and CyaY is shown to be an iron-dependent inhibitor of iron-sulfur cluster formation by binding to but not inhibiting the activity of IscS (Adinolfi, 2009). CyaY forms iron-promoted aggregates in vitro, but not at physiological salt concentrations. There is no iron accumulation or oxidative stress defect in cyaY mutant or overproducing strains. cyaY is expressed, as measured using LacZ fusions (Trotot, 1996). A dubious 116 codon ORF named cyaX on the opposite strand of cyaY was dropped (Aiba, 1984).

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BamHI EcoRI HindIII