GenePage for the acrA gene of Escherichia coli K-12

Primary Gene Name: acrA
EcoGene Accession Number: EG11703
K-12 Gene Accession Number: ECK0457
MG1655 Gene Identifier: b0463
Gene Name Mnemonic: Acridine
Alternate Gene Symbols: lir; Mb; mbl; mtcA; nbsA; sipB
Description: AcrAB-TolC multidrug efflux pump; additionally dye, detergent, solvent resistance; membrane-fusion lipoprotein
  # bp Upstream # bp Downstream
MW: 42196.71 ---------397 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 484426
Left Intergenic Region

Name: acrB_acrA

Length: 22 bp gap

Orientation: Codirectional-

Left_end: 484404

Right_end: 484425

Centisome: 10.44

Genomic Address
Counterclockwise
Minute or Centisome (%) = 10.44
Right End: 485619
Right Intergenic Region

Name: acrA_acrR

Length: 141 bp gap

Orientation: Divergent

Left_end: 485620

Right_end: 485760

Centisome: 10.46

acrA was first identified as an acridine sensitive mutation. acrA is a mutational suppressor of topA deletion inviability in low osmolarity medium. AcrA is attached to the inner membrane. acrA is an acrE paralog. AcrA is trimeric. Mar regulon. The first 24 aa of AcrA are a type II signal peptide.

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BamHI EcoRI HindIII