GenePage for the aidB gene of Escherichia coli K-12

Primary Gene Name: aidB
EcoGene Accession Number: EG11811
K-12 Gene Accession Number: ECK4183
MG1655 Gene Identifier: b4187
Gene Name Mnemonic: Alkylating agent induced
Alternate Gene Symbols: None
Description: DNA alkylation damage repair protein; flavin-containing DNA binding protein, weak isovaleryl CoA dehydrogenase
  # bp Upstream # bp Downstream
MW: 60589.90 ---------541 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4414275
Left Intergenic Region

Name: yjfC_aidB

Length: 83 bp gap

Orientation: Codirectional+

Left_end: 4414192

Right_end: 4414274

Centisome: 95.10

Genomic Address
Clockwise
Minute or Centisome (%) = 95.10
Right End: 4415900
Right Intergenic Region

Name: aidB_yjfN

Length: 116 bp gap

Orientation: Convergent

Left_end: 4415901

Right_end: 4416016

Centisome: 95.14

AidB has low level isovaleryl CoA dehydrogenase activity, binds flavin, and binds DNA (Rohankhedk, 2006). The C-terminal 100 aa domain of AidB preferentially binds its own promoter region in vitro and auto-represses in vivo (Rippa, 2010). AidB overexpression reduces nitrosoguanidine-induced alkylation mutagenesis (Landini, 1994). aidB is in the GadE regulon (Marbach, 2012). Ada regulon. aidB is induced by anaerobiosis and acetate, dependent on RpoS. AidB may bind DNA to protect it from alkylating agents; a substrate yielding a robust acyl dehydrogenase activity has yet to be found.

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BamHI EcoRI HindIII