GenePage for the elyC gene of Escherichia coli K-12

Primary Gene Name: elyC
EcoGene Accession Number: EG12166
K-12 Gene Accession Number: ECK0911
MG1655 Gene Identifier: b0920
Gene Name Mnemonic: Elevated frequency of LYsis
Alternate Gene Symbols: ycbC
Description: Envelope biogenesis factor; DUF218 superfamily protein
  # bp Upstream # bp Downstream
MW: 28666.35 ---------259 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 972622
Left Intergenic Region

Name: ycbJ_elyC

Length: 24 bp overlap

Orientation: Convergent

Left_end: 972622

Right_end: 972645

Centisome: 20.95

Genomic Address
Minute or Centisome (%) = 20.95
Right End: 973401
Right Intergenic Region

Name: elyC_smtA

Length: 135 bp gap

Orientation: Divergent

Left_end: 973402

Right_end: 973536

Centisome: 20.97

ElyC may be involved in the competition between the PG and ECA synthetic pathways for the lipid carrier undecaprenyl pyrophosphate; elyC(ycbC) mutants are cold-sensitive (CS) for growth due to cell lysis; ; ispU(uppS), murA, and mrcB are multi-copy suppressors of elyC; rmlA-elyC and wecF-elyC are synthetic lethal double mutant pairs presumably due to the accumulation of ECA precursors since an early pathway block imposed by a third mutation in the wecA gene suppresses both synthetic lethal phenoytpes; ydcF and elyC(ycbC) (COG1434) and sanA and ygjQ (COG2949) are four members of the DUF218 superfamily (PF02698), but only elyC complemennt the CS phenotype (Paradis-Bleau, 2014).

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