GenePage for the gadW gene of Escherichia coli K-12

Primary Gene Name: gadW
EcoGene Accession Number: EG12242
K-12 Gene Accession Number: ECK3499
MG1655 Gene Identifier: b3515
Gene Name Mnemonic: Glutamic acid decarboxylase
Alternate Gene Symbols: yhiW
Description: Transcriptional activator of gadA and gadBC; repressor of gadX
  # bp Upstream # bp Downstream
MW: 28028.45 ---------242 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3663890
Left Intergenic Region

Name: mdtF_gadW

Length: 362 bp gap

Orientation: Convergent

Left_end: 3663528

Right_end: 3663889

Centisome: 78.93

Genomic Address
Counterclockwise
Minute or Centisome (%) = 78.94
Right End: 3664618
Right Intergenic Region

Name: gadW_gadY

Length: 245 bp gap

Orientation: Divergent

Left_end: 3664619

Right_end: 3664863

Centisome: 78.95

GadW is a transcriptional activator of the gadA gene and the gadBC operon working both in conjunction with or independent of GadX. pgsA mutants are non-motile due to elevated RpoS levels that repress flhDC transcription; pgsA3 multicopy suppressers gadW, metE and nudL(yeaB) act by increasing RpoS levels (Uchiyama, 2010). AraC family.

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BamHI EcoRI HindIII