GenePage for the ccp gene of Escherichia coli K-12

Primary Gene Name: ccp
EcoGene Accession Number: EG12244
K-12 Gene Accession Number: ECK3503
MG1655 Gene Identifier: b3518
Gene Name Mnemonic: Cytochrome c peroxidase
Alternate Gene Symbols: yhjA
Description: Cytochrome c peroxidase; Ccp; anaerobic respiratory oxidase, hydrogen peroxide-inducible, periplasmic
  # bp Upstream # bp Downstream
MW: 51570.55 ---------465 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3667791
Left Intergenic Region

Name: gadA_ccp

Length: 210 bp gap

Orientation: Codirectional-

Left_end: 3667581

Right_end: 3667790

Centisome: 79.01

Genomic Address
Counterclockwise
Minute or Centisome (%) = 79.02
Right End: 3669188
Right Intergenic Region

Name: ccp_treF

Length: 403 bp gap

Orientation: Divergent

Left_end: 3669189

Right_end: 3669591

Centisome: 79.05

Cytochrome c peroxidase (Ccp) is a hydrogen peroxide-inducible membrane-anchored periplasmic anaerobic respiratory oxidase enabling the use of micromolar concentrations of exogenous hydrogen peroxide as a terminal electron acceptor during anaerobic growth, as proposed earlier; menaquinone is the electron donor; the Ccm pathway is the source of the c-type heme in Ccp (Atack, 2007; Mishra, 2012; Khademian, 2017). Mutants in ccp(yhjA) are sensitive to exogenous hydrogen peroxide and organic peroxides during anaerobic growth; ccp(yhjA) is regulated by FNR and OxyR (Partridge, 2007). Ccp(YhjA) was predicted to have a cleavable signal peptide by SignalP 3.0 but is now predicted to have a non-cleavable signal peptide that also serves as an N-terminal membrane anchor for periplasmic Ccp by SignalP 4.0, which was specifically designed to discriminate between cleavable signal peptides and transmembrane segments; the same prediction is made in the Membranome database (Bendtsen, 2004; Peterson, 2011; Lomize, 2017).

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BamHI EcoRI HindIII