GenePage for the gpmM gene of Escherichia coli K-12

Primary Gene Name: gpmM
EcoGene Accession Number: EG12296
K-12 Gene Accession Number: ECK3602
MG1655 Gene Identifier: b3612
Gene Name Mnemonic: Glycerol P mutase, Mn-dependent
Alternate Gene Symbols: gpmC; gpmI; pgmI; yibO
Description: Phosphoglycerate mutase, Mn-dependent, cofactor-independent; iPGM; monomeric
  # bp Upstream # bp Downstream
MW: 56193.89 ---------514 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3785260
Left Intergenic Region

Name: yibN_gpmM

Length: 244 bp gap

Orientation: Divergent

Left_end: 3785016

Right_end: 3785259

Centisome: 81.54

Genomic Address
Clockwise
Minute or Centisome (%) = 81.55
Right End: 3786804
Right Intergenic Region

Name: gpmM_envC

Length: 33 bp gap

Orientation: Codirectional+

Left_end: 3786805

Right_end: 3786837

Centisome: 81.58

Salmonella typhimurium gpmM mutants grow poorly on minimal media supplemented with various carbon sources (Kehres, 2003). E. coli gpmM mutants do not have a growth defect on minimal medium with glucose but alternative carbon sources were not tested (Foster, 2010). Purified GpmA has 10-20 times higher specific actvity than GpmM (Fraser, 1999; Foster, 2010). Purified GpmM contains Mn(2+) (Fraser, 1999). GpmM has four-fold higher specific activity with Mn(2+) than Mg(2+); Co(2+) also stimulated activity (Foster, 2010). gpmM and gpmA are non-essential genes but phosphoglycerate mutase is an essential enzyme since a gpmA gpmM double mutation is lethal (Foster, 2010). The yibN-envC,gpmM,yibQ divergent operon promoter region binds FNR and envC-gpmM-yibQ expression is activated by FNR (Federowicz, 2014). HT_Cmplx25_Cyt: GpmA+GpmM.

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BamHI EcoRI HindIII