GenePage for the bamA gene of Escherichia coli K-12

Primary Gene Name: bamA
EcoGene Accession Number: EG12676
K-12 Gene Accession Number: ECK0176
MG1655 Gene Identifier: b0177
Gene Name Mnemonic: Beta-barrel assembly machine
Alternate Gene Symbols: ecfK; omp85(N.m.); yaeT; yzzN; yzzY
Description: Outer membrane protein required for OM biogenesis; in BamABCDE complex; forms pores; PORTA repeats
  # bp Upstream # bp Downstream
Verified Start MW: 90552.77 ---------810 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 197928
Left Intergenic Region

Name: rseP_bamA

Length: 29 bp gap

Orientation: Codirectional+

Left_end: 197899

Right_end: 197927

Centisome: 4.26

Genomic Address
Minute or Centisome (%) = 4.26
Right End: 200360
Right Intergenic Region

Name: bamA_skp

Length: 121 bp gap

Orientation: Codirectional+

Left_end: 200361

Right_end: 200481

Centisome: 4.32

BamA has a C-terminal beta-barrel OM protein domain and an N-terminal periplasmic domain with five PORTA (polypeptide transport-associated) repeats that bind OM substrate peptides (Gatsos, 2008, Knowles, 2008; Ward, 2009). bamA is an essential gene. The ATG at codon 3 could be the true start codon. bamA is the last gene in the ispU-cdsA-rseP-bamA operon. HT_Cmplx49_Mem: DamX+BamA. ytfM and bamA are paralogs. An erroneous inner membrane localization may indicate binding to an inner membrane protein or cross-contamination (Lopez-Campistrous, 2005). otherPDB(H.ducreyi): 4K3C (Noinaj, 2014). otherPDB(N.gonorrhoeae): 4K3B (Noinaj, 2013).

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