GenePage for the copA gene of Escherichia coli K-12
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Primary Gene Name: copA EcoGene Accession Number: EG13246 K-12 Gene Accession Number: ECK0478 MG1655 Gene Identifier: b0484 |
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Gene Name Mnemonic: Copper Alternate Gene Symbols: ybaR Description: Copper and silver-translocating P-type ATPase efflux pump; CopA(Z) metallochaperone; involved in copper resistance; copper- and silver-inducible; regulated by copper-responsive CueR activator |
| Verified Start | MW: 87873.14 ---------834 aa |
Pre-Run BlastP UniProt Pre-Run BlastP NR+Env |
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Left End: 508875 Left Intergenic Region Name: ybaQ_copA Length: 315 bp gap Orientation: Convergent Left_end: 508560 Right_end: 508874 Centisome: 10.96 |
Genomic Address Counterclockwise Minute or Centisome (%) = 10.96 |
Right End: 511379 Right Intergenic Region Name: copA_glsA Length: 261 bp gap Orientation: Divergent Left_end: 511380 Right_end: 511640 Centisome: 11.02 |
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CopA produces a 70 aa metallochaperone named CopA(Z) from its first 69 residues plus a C-terminal glycine added after a programmed frameshift (Meydan, 2017; Drees, 2017). CopA contains a putative phosphatase HAD domain: residues 516-740. CusF is a periplasmic copper-, silver-binding protein that may work with CopA. Alternatively, YobA may be a CopC-like periplasmic copper-binding protein that works with CopA. copA is upregulated by GSNO in defined medium (anaerobic). HAD superfamily.
