GenePage for the glsA gene of Escherichia coli K-12

Primary Gene Name: glsA
EcoGene Accession Number: EG13247
K-12 Gene Accession Number: ECK0479
MG1655 Gene Identifier: b0485
Gene Name Mnemonic: GLutanimaSe
Alternate Gene Symbols: glsA1; ybaS
Description: Glutaminase 1, GlsA1
  # bp Upstream # bp Downstream
MW: 32903.32 ---------310 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 511641
Left Intergenic Region

Name: copA_glsA

Length: 261 bp gap

Orientation: Divergent

Left_end: 511380

Right_end: 511640

Centisome: 11.02

Genomic Address
Clockwise
Minute or Centisome (%) = 11.02
Right End: 512573
Right Intergenic Region

Name: glsA_ybaT

Length: 2 bp gap

Orientation: Codirectional+

Left_end: 512574

Right_end: 512575

Centisome: 11.04

GlsA and GadC form an acid resistance system sufficient to protect E. coli from acid stress in the pressence of glutamine (Lu, 2013). Early experiments suggesed that GlsA(YbaS) might contribute to acid resistance, as was later demonstrated (Brown, 2008). glsA(ybaS) is in the CueR regulon (Marbach, 2012). glsA(ybaS) may be in the GadE regulon; weak support (Marbach, 2012). Two glutaminases have been purified and biochemically characterized from E. coli B.

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BamHI EcoRI HindIII