GenePage for the frmR gene of Escherichia coli K-12

Primary Gene Name: frmR
EcoGene Accession Number: EG13296
K-12 Gene Accession Number: ECK0354
MG1655 Gene Identifier: b0357
Gene Name Mnemonic: Formaldehyde
Alternate Gene Symbols: yaiN
Description: Negative regulator of the frmRAB operon
  # bp Upstream # bp Downstream
MW: 10317.72 ---------91 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 379606
Left Intergenic Region

Name: frmA_frmR

Length: 34 bp gap

Orientation: Codirectional-

Left_end: 379572

Right_end: 379605

Centisome: 8.18

Genomic Address
Counterclockwise
Minute or Centisome (%) = 8.18
Right End: 379881
Right Intergenic Region

Name: frmR_yaiO

Length: 187 bp gap

Orientation: Codirectional-

Left_end: 379882

Right_end: 380068

Centisome: 8.18

The frmRAB operon is negatively regulated by frmR, is induced by formaldehyde, and probably degrades formaldehyde. An amber suppressor allows readthrough of frmR, adding 7 aa, which inactivates FrmR, causing stimulation of frmRAB transcription. frmR and rcnR are paralogs.

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BamHI EcoRI HindIII