GenePage for the cbeA gene of Escherichia coli K-12

Primary Gene Name: cbeA
EcoGene Accession Number: EG13388
K-12 Gene Accession Number: ECK1997
MG1655 Gene Identifier: b2004
Gene Name Mnemonic: Cytoskeleton Bundling-Enhancing factor A
Alternate Gene Symbols: yeeU
Description: Cytoskeleton bundling-enhancing factor A, CbtA antitoxin; CP4-44 putative defective prophage
  # bp Upstream # bp Downstream
MW: 13683.58 ---------122 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2077112
Left Intergenic Region

Name: yeeT_cbeA

Length: 73 bp gap

Orientation: Codirectional+

Left_end: 2077039

Right_end: 2077111

Centisome: 44.75

Genomic Address
Clockwise
Minute or Centisome (%) = 44.75
Right End: 2077480
Right Intergenic Region

Name: cbeA_cbtA

Length: 88 bp gap

Orientation: Codirectional+

Left_end: 2077481

Right_end: 2077568

Centisome: 44.76

Unlike other antitoxins, CbeA(YeeU) does not act by binding to the CbtA toxin, but by stabilizing the CbtA cytoskeletal protein targets MreB and FtsZ by enhancing their polymeric bundling; CbeA also antagonizes the effects of other cytoskeletal disrupting agents such as A22, SulA and MinC (Masuda, 2012). The crystal structure of CbeA(YeeU) has been solved (2H28) and the CbeA(YeeU) antitoxin is structurally related to the RelE and YoeB toxins (Arbing, 2010).

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BamHI EcoRI HindIII