GenePage for the glrK gene of Escherichia coli K-12

Primary Gene Name: glrK
EcoGene Accession Number: EG13461
K-12 Gene Accession Number: ECK2553
MG1655 Gene Identifier: b2556
Gene Name Mnemonic: GLmy-Regulating Kinase
Alternate Gene Symbols: qseE; yfhK; yfhZ
Description: Sensor protein kinase regulating glmY sRNA; cognate response regulator is GlrR(QseF)
  # bp Upstream # bp Downstream
MW: 53330.41 ---------475 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2689671
Left Intergenic Region

Name: yfhG_glrK

Length: 164 bp gap

Orientation: Codirectional-

Left_end: 2689507

Right_end: 2689670

Centisome: 57.94

Genomic Address
Counterclockwise
Minute or Centisome (%) = 57.95
Right End: 2691098
Right Intergenic Region

Name: glrK_glmY

Length: 58 bp gap

Orientation: Codirectional-

Left_end: 2691099

Right_end: 2691156

Centisome: 57.98

GlrK(QseE,YfhK) signals GlrR(QseF,YfhA) to bind the glmY promoter and activate a sigma-54 (RpoN) promoter that overlaps the sigma-70 (RpoD) promoter (Reichenbach, 2009). Also characterized in an EPEC strain, QseC activates transcription of qseEGF(glrK-yfhG-glrR) in response to the autoinducer-3 (AI-3)/epinephrine/norepinephrine interkingdom signaling system (Reading, 2007). The sensor kinase QseE(GlrK) is responsive to epinephrine, sulfate and phosphate and transcription is activated by AI-3/epinephrine/norepinephrine via QseC in EPEC (Reading, 2007). GlrK(QseE,YfhK) phosphorylates GlrR(QseF,YfhA) and has autokinase activity in vitro (Yamamoto, 2005). QseEF also responds directly to epinephrine, sulfate and phosphate in EPEC (Reading, 2009).

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BamHI EcoRI HindIII