GenePage for the csiD gene of Escherichia coli K-12

Primary Gene Name: csiD
EcoGene Accession Number: EG13523
K-12 Gene Accession Number: ECK2653
MG1655 Gene Identifier: b2659
Gene Name Mnemonic: Carbon starvation induced
Alternate Gene Symbols: csi-12; gab; ygaT
Description: Carbon starvation induced protein; tetrameric; 2-oxoglutarate Fe(II)-dependent oxygenase-like protein
  # bp Upstream # bp Downstream
Verified Start MW: 37360.41 ---------325 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2788985
Left Intergenic Region

Name: ygaQ_csiD

Length: 335 bp gap

Orientation: Codirectional+

Left_end: 2788650

Right_end: 2788984

Centisome: 60.08

Genomic Address
Minute or Centisome (%) = 60.09
Right End: 2789962
Right Intergenic Region

Name: csiD_lhgO

Length: 19 bp gap

Orientation: Codirectional+

Left_end: 2789963

Right_end: 2789981

Centisome: 60.11

csiD is the first gene in csiD-lhgO-gabDTP operon. csiD is a carbon starvation-inducible gene that is regulated by RpoS, cAMP-CRP, HN-S and Lrp (Marschal, 1998). The structure of CsiD(Gab) indicates that it is distantly related to 2-oxoglutarate (2-OG) Fe(II)-dependent oxygenases; both CsiD(Gab) and the 2-OG oxygenases belong to the Cupin (jelly-roll) protein clan (Pfam CL0029); gel filtration and structure indicates it is a tetramer; 2-OG is a substrate for GabT and thus CsiD(Gab) may be involved in GABA metabolism or regulation; an iron ion is coordinated by His160, His292 and Asp162; Arg305 is conserved bewteen CsiD(Gab) the 2-OG oxygenases in which it binds substrate carboxylate groups indicating that CsiD(Gab) is likely to also utilize a substrate with a carboxylate group (Chance, 2002).

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