GenePage for the ecpD gene of Escherichia coli K-12

Primary Gene Name: ecpD
EcoGene Accession Number: EG13562
K-12 Gene Accession Number: ECK0289
MG1655 Gene Identifier: b0290
Gene Name Mnemonic: E. coli common pilus
Alternate Gene Symbols: matE; yagW
Description: Polymerized tip adhesin of ECP fibers
  # bp Upstream # bp Downstream
MW: 59997.10 ---------547 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 305174
Left Intergenic Region

Name: ecpE_ecpD

Length: 32 bp overlap

Orientation: Codirectional-

Left_end: 305174

Right_end: 305205

Centisome: 6.57

Genomic Address
Counterclockwise
Minute or Centisome (%) = 6.57
Right End: 306817
Right Intergenic Region

Name: ecpD_ecpC

Length: 11 bp overlap

Orientation: Codirectional-

Left_end: 306807

Right_end: 306817

Centisome: 6.61

EcpD has its own N-terminal extension (NTE) and can polymerize by itself as well as at the tips of EcpA fibers (Garnett, 2012). The O18ac:K1:H7 NMEC ecpRAB(matABC) genes are required for E. coli common pilus (Mat fimbria) formation when cloned in K-12; (Pouttu, 2001).The E. coli O18ac:K1:H7 NMEC ecpABCDE(matBCDEF) genes are all individually required for E. coli common pilus (ECP) formation in the pathogenic E.coli NMEC strains and ECP production enhances low-temperature biofilm formation in NMEC and and also in K-12 when the silent ecp operon is expressed; ecpR(matA) mRNA was detected in K-12, but not ecpAB(matBC) mRNA (Pouttu, 2001; Lehti, 2010; Garnett, 2012). The first 23 aa of EcpD are predicted to be a type I signal peptide, but it may be a signal anchor.

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BamHI EcoRI HindIII