GenePage for the djlB gene of Escherichia coli K-12

Primary Gene Name: djlB
EcoGene Accession Number: EG13649
K-12 Gene Accession Number: ECK0639
MG1655 Gene Identifier: b0646
Gene Name Mnemonic: DnaJ-like
Alternate Gene Symbols: ybeS
Description: Predicted HscC co-chaperone; uncharacterized J domain-containing protein
  # bp Upstream # bp Downstream
MW: 55256.33 ---------475 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 677415
Left Intergenic Region

Name: ybeR_djlB

Length: 4 bp overlap

Orientation: Codirectional+

Left_end: 677415

Right_end: 677418

Centisome: 14.59

Genomic Address
Minute or Centisome (%) = 14.59
Right End: 678842
Right Intergenic Region

Name: djlB_ybeT

Length: 9 bp gap

Orientation: Convergent

Left_end: 678843

Right_end: 678851

Centisome: 14.63

DjlB is an uncharacterized DnaJ homolog (J domain-containing protein, JDP) that is a predicted HscC co-chaperone stimulating its chaperone partner's ATPase activity because of its similarities to known type III JDP DjlC HscC co-chaperone including (a) 50% protein sequence identity (65% similarity), (b) conserved N-terminal DnaK-like protein-interacting J-domains, (c) membrane tail-anchors (TAMP proteins) and (d) hscC-proximal gene locations; however, because DjlB overproduction is toxic it has not been purified or tested for HscC co-chaperone activity (Itoh, 1999; Kluck, 2002). djlB djlC double mutants are viable and have a reduced growth yield in the presence of cadmium (Kluck, 2002). The djlB mutants in the Keio collection have been shown to harbor an intact copy of djlB in addition to the deletion allele (Yamamoto, 2009).

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