GenePage for the gfcA gene of Escherichia coli K-12

Primary Gene Name: gfcA
EcoGene Accession Number: EG13732
K-12 Gene Accession Number: ECK0978
MG1655 Gene Identifier: b0987
Gene Name Mnemonic: Group 4 Capsule
Alternate Gene Symbols: ymcD
Description: Threonine-rich inner membrane protein; required to make O-antigen capsule
  # bp Upstream # bp Downstream
MW: 9507.50 ---------101 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1049439
Left Intergenic Region

Name: gfcB_gfcA

Length: 106 bp gap

Orientation: Codirectional-

Left_end: 1049333

Right_end: 1049438

Centisome: 22.61

Genomic Address
Counterclockwise
Minute or Centisome (%) = 22.61
Right End: 1049744
Right Intergenic Region

Name: gfcA_insA4

Length: 88 bp gap

Orientation: Divergent

Left_end: 1049745

Right_end: 1049832

Centisome: 22.62

E. coli K-12 does not produce O-antigen capsule polysaccharide because the cryptic gfcABCDE-etp-etk operon is silenced by IS1D in the promoter region (Peleg, 2005). GfcA is required for O-antigen capsule formation in enteropathogenic E. coli (EPEC) (Peleg, 2005). GfcA is an inner membrane protein with a periplasmic C-tail (Daley, 2005). gfcA(ymcD) and yjbE are paralogs. The first 21 aa of GfcA are predicted to be a type I signal peptide.

Go to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePage

BamHI EcoRI HindIII