GenePage for the hicB gene of Escherichia coli K-12

Primary Gene Name: hicB
EcoGene Accession Number: EG13760
K-12 Gene Accession Number: ECK1432
MG1655 Gene Identifier: b1438
Gene Name Mnemonic: hif contiguous (from H. influenzae ortholog)
Alternate Gene Symbols: ydcQ
Description: Antitoxin of HicAB TA pair; mutational suppressor of null rpoE lethality
  # bp Upstream # bp Downstream
MW: 15246.63 ---------138 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1509508
Left Intergenic Region

Name: hicA_hicB

Length: 45 bp gap

Orientation: Codirectional+

Left_end: 1509463

Right_end: 1509507

Centisome: 32.52

Genomic Address
Clockwise
Minute or Centisome (%) = 32.52
Right End: 1509924
Right Intergenic Region

Name: hicB_ydcR

Length: 78 bp gap

Orientation: Codirectional+

Left_end: 1509925

Right_end: 1510002

Centisome: 32.53

IS insertions in hicA(ydcQ) were isolated as suppressors of rpoE lethality; in wildtype cells, hicA(ydcQ) mutants downregulate extracytoplasmic stress responses and OM vesicle production is reduced (Button, 2006). PF01381 family. A longer 145 aa translation is unlikely due to a poor RBS and a lack of sequence conservation.

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BamHI EcoRI HindIII