GenePage for the dosC gene of Escherichia coli K-12

Primary Gene Name: dosC
EcoGene Accession Number: EG13793
K-12 Gene Accession Number: ECK1484
MG1655 Gene Identifier: b1490
Gene Name Mnemonic: Direct oxygen sensor cyclase
Alternate Gene Symbols: yddV
Description: Diguanylate cyclase, binds oxygen, positive biofilm regulator; cold- and stationary phase-induced
  # bp Upstream # bp Downstream
MW: 53177.70 ---------460 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1565758
Left Intergenic Region

Name: dosP_dosC

Length: 24 bp gap

Orientation: Codirectional-

Left_end: 1565734

Right_end: 1565757

Centisome: 33.73

Genomic Address
Minute or Centisome (%) = 33.73
Right End: 1567140
Right Intergenic Region

Name: dosC_yddW

Length: 363 bp gap

Orientation: Codirectional-

Left_end: 1567141

Right_end: 1567503

Centisome: 33.76

DosCP regulates biofilm formation through the oxygen-dependent activation of the csgBAC operon (Tagliabue, 2010a). DosCP may constitute a cyclic-di-GMP synthesis/degradation module (Mendez-Ortiz, 2006; Tuckerman, 2009). Overexpression of DosC(YddV), but not other DGCs, up-regulates the pgaABCD operon and biofilm formation independently of CsrA, and a dosC(yddV) mutant has reduced pgaABCD expression (Tagliabue, 2010b). Overexpressed DosC(YddV) complements R. leguminosarum celR mutants to produce cellulose and enhances cellulose production in A. tumefaciens. DosC(YddV) can complement Salmonella adrA. DosC(YddV) has an N-terminal GCSD(Globin-Coupled-Sensor Domain) that binds oxygen (Tuckerman, 2009). DosC(YddV) has a C-terminal diguanylate cyclase GGDEF domain. dosCP is an operon and DosCP is a protein complex (Tuckerman, 2009). DosC(YddV) has been mislabeled as YhcK, the name of a B. subtilis homolog of YedQ. RpoS regulon (Weber, 2006).

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