GenePage for the efeO gene of Escherichia coli K-12

Primary Gene Name: efeO
EcoGene Accession Number: EG13861
K-12 Gene Accession Number: ECK1008
MG1655 Gene Identifier: b1018
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: ycdO
Description: Inactive acid-inducible low-pH ferrous ion transporter EfeUOB; acid-inducible periplasmic protein
  # bp Upstream # bp Downstream
MW: 41137.63 ---------375 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1082243
Left Intergenic Region

Name: efeU_efeO

Length: 57 bp gap

Orientation: Codirectional+

Left_end: 1082186

Right_end: 1082242

Centisome: 23.31

Genomic Address
Clockwise
Minute or Centisome (%) = 23.32
Right End: 1083370
Right Intergenic Region

Name: efeO_efeB

Length: 5 bp gap

Orientation: Codirectional+

Left_end: 1083371

Right_end: 1083375

Centisome: 23.34

The EfeUOB tripartite iron transporter is silent in E. coli K-12 due to a mutation in EfeU (Cao, 2007). efeO(ycdO) has been reported to be both an essential gene (DeVito, 2002) and non-essential (Baba, 2006). The Tat-targeting of EfeO(YcdO) translocation could not be assessed (Tullman-Ercek, 2007). The first 26 aa of efeO have been confirmed to be a type I signal peptide by electrospray MS of the intact periplasmic protein (Sturm, 2006). efeUOB of K-12 are transcribed as an iron-depletion-inducible, Fur-dependent operon (McHugh, 2003; Grosse, 2006). EfeO(YcdO) protein levels increased after 30 min of Zn(II) stress (Easton, 2006). Mutations in efeO have a hyperlethality phenotype when cells are stressed; EfeO is a protein that reduces the lethal effects of stress (Han, 2010).

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BamHI EcoRI HindIII