GenePage for the istR gene of Escherichia coli K-12
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Primary Gene Name: istR EcoGene Accession Number: EG31167 K-12 Gene Accession Number: ECK4425 MG1655 Gene Identifier: b4616 |
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Gene Name Mnemonic: inhibitor of SOS-induced toxicity Alternate Gene Symbols: psr19; psrA19 Description: sRNAs IstR-1 and IstR-2, tisB regulators |
| MW: 45130.87 ---------140 nt | Pre-Run BlastN |
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Left End: 3853118 Left Intergenic Region Name: ivbL_istR Length: 129 bp gap Orientation: Codirectional- Left_end: 3852989 Right_end: 3853117 Centisome: 83.01 |
Genomic Address Counterclockwise Minute or Centisome (%) = 83.01 |
Right End: 3853257 Right Intergenic Region Name: istR_tisB Length: 295 bp gap Orientation: Divergent Left_end: 3853258 Right_end: 3853552 Centisome: 83.01 |
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IstR-1 (75 bp) is initiated from an internal promoter; lstR-2 is lexA-regulated, possibly mitigating the lstR-1 antisense inhibition of residual TisB translation during the SOS response (Vogel, 2004). The antisense sRNA IstR binds to and blocks an upstream ribosome loading standby site required for translation initiation of TisB; ribosomes probably slide to the highly structured downstream TIR after loading; this results in RNase III cleavage of the active, processed +42 tisB mRNA to form an inactive +106 tisB mRNA (Darfeuille, 2007).
