GenePage for the chiX gene of Escherichia coli K-12

Primary Gene Name: chiX
EcoGene Accession Number: EG31175
K-12 Gene Accession Number: ECK4396
MG1655 Gene Identifier: b4585
Gene Name Mnemonic: chitin
Alternate Gene Symbols: er13; micM; rybC; sroB
Description: sRNA regulator of OM chitoporin ChiP(YbfM); also an antisense regulator for CitA(DpiB)
  # bp Upstream # bp Downstream
MW: 27092.16 ---------84 nt Pre-Run BlastN
Left End: 507204
Left Intergenic Region

Name: ybaK_chiX

Length: 121 bp gap

Orientation: Divergent

Left_end: 507083

Right_end: 507203

Centisome: 10.92

Genomic Address
Clockwise
Minute or Centisome (%) = 10.93
Right End: 507287
Right Intergenic Region

Name: chiX_ybaP

Length: 2 bp overlap

Orientation: Convergent

Left_end: 507286

Right_end: 507287

Centisome: 10.93

ChiX(MicM) silences chiP(ybfM) mRNA, blocking translation and causing the chiPQ(ybfMN) mRNA to be degraded (Rasmussen, 2009). Upregulation of a chb operon-encoded trap-mRNA (the chbBC intergenic region acting as an anti-antisense RNA) causes degradation of the micM sRNA, leading to induction of chiP(ybfM) mRNA translation (Overgaard, 2009). ChiX(MicM) has been independently characterized in Salmonella, and the Salmonella name chiX is used for the E. coli sRNA as well (Figueroa-Bossi, 2009). ChiX(RybC,MicM) regulates citAB(dpiBA) mRNA; citAB(dpiBA) mRNA may be another ChiX trap-mRNA (also called an RNA decoy) as well (Mandin, 2009).

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BamHI EcoRI HindIII